5-MTHF L-Methylfolate (Folic Acid)
5-MTHF L-Methylfolate from Greatlife is a high-quality form of folic acid, specifically in the easily absorbable 5-MTHF L-Methylfolate form. This active form of folic acid, from the patented Quatrefolic® brand, ensures efficient absorption and is ideal for the body. 5-MTHF L-Methylfolate contributes to tissue growth during pregnancy and supports normal cell division. This supplement is pure, free from additives, toxins, and GMOs.
- Folic acid/folate in the easily absorbed form 5-MTHF L-Methylfolate
- Active form of folic acid from Quatrefolic®
- Contributes to tissue growth during pregnancy.
- Free from dairy, soy, sugar, gluten, and GMOs
- Free from artificial sweeteners, colourings, preservatives, hydrogenated oils, corn syrup, and magnesium stearate
- Dark glass jar, free from BPA, phthalates, and other hormone-disrupting substances
- Manufactured under HACCP in the EU
- Suitable for vegans and vegetarians
- Buy now, pay later
- Ship all over Europe
- In stock
5-MTHF L-Methylfolate (Folic Acid)
5-MTHF L-Methylfolate from Greatlife is a powerful supplement that promotes cell growth, tissue repair, and a healthy pregnancy. 5-MTHF L-Methylfolate, the active and easily absorbed form of folic acid, plays a crucial role in the body's folate metabolism and is essential for proper cell division and tissue formation. This form of folic acid is especially beneficial for pregnant women, as it contributes to tissue growth and normal fetal development.
5-MTHF L-Methylfolate also supports heart health and may help keep blood homocysteine levels within normal ranges, which is important for cardiovascular health. This active form is more bioavailable than regular folic acid, making it an optimal choice to ensure effective folate absorption and support the body's health naturally.
Studies have shown that 5-MTHF L-Methylfolate is an effective alternative to traditional folic acid, particularly for those who have difficulty converting folic acid into the active form.
Quatrefolic® is a patented form of the active folate form, 5-methyl-tetrahydrofolate, which is naturally present in the body and is directly available for biological activity.
Folate plays a vital role in several important functions in the body. It contributes to tissue growth in pregnant women and is essential for normal amino acid synthesis and blood formation. Folate also supports normal homocysteine metabolism and contributes to normal psychological function, which is important for mental well-being. Additionally, folate supports the normal function of the immune system and helps reduce fatigue and exhaustion. Folate also plays an important role in cell division, which is crucial for cell growth and repair.
The MTHFR Gene
The MTHFR gene (Methylenetetrahydrofolate reductase) plays an important role in the body’s folate metabolism. It is responsible for converting folate (vitamin B9) into an active form called 5-MTHF (5-Methyltetrahydrofolate). 5-MTHF is the form of folate that the body can use for essential processes such as amino acid synthesis, blood formation, and homocysteine metabolism.
Folate is an important nutrient for everyone, but individuals with a genetic variation in the MTHFR gene may have difficulty converting folate into 5-MTHF. This can lead to folate deficiency even when they are consuming adequate amounts of folate from their diet. It may also affect homocysteine levels in the blood, which in turn can impact cardiovascular health.
Therefore, for people with the MTHFR variation, it is recommended to take folate in its already active form, 5-MTHF, to ensure that the body can use it effectively. By taking 5-MTHF instead of regular folic acid, they can avoid conversion issues and achieve better results in their health, particularly when it comes to supporting cell growth, blood formation, and heart health.
This supplement is free from dairy, soy, sugar, gluten, and GMOs, as well as artificial sweeteners, colourants, preservatives, hydrogenated oils, corn syrup, and magnesium stearate. It is delivered in a dark glass jar that is free from BPA, phthalates, and other endocrine-disrupting substances. The manufacturing process follows HACCP standards in the EU, and the product is suitable for both vegans and vegetarians.
| Content per daily dose (1 capsule) | % of RDA | |
|---|---|---|
| Folic acid as L-Methylfolate 5-MTHF (Quatrefolic®) | 600 μg | 300 |
RDA = Recommended Daily Allowance
* RDA not established
Other Ingredients
Microcrystalline cellulose (filler), vegetable capsule (hydroxypropylmethylcellulose).
Dosage
Take 1 capsule daily, preferably in the morning and with a meal. If you have difficulty swallowing, the capsule can be opened and the contents sprinkled onto food or into a drink that is consumed immediately.
Note
The recommended daily dose should not be exceeded. Keep out of reach of children. Food supplements should not be used as a substitute for a varied diet. A diverse and balanced diet, along with a healthy lifestyle, are important. Store in a dry, dark place at room temperature. Never place food supplements in direct sunlight, in a damp environment, or near a heat source. Consult your doctor before use if you are pregnant, breastfeeding, or have a medical condition. Store in a cool, dry place. Manufactured in the EU. Close the container tightly.
What is folic acid and folate, and why are they so important for the body?
Folate is the natural form of vitamin B9, found in foods such as leafy green vegetables, eggs, and liver. Folic acid is the synthetic form of the same vitamin, used in supplements and fortified foods. Both forms serve the same essential function in the body; they are needed for cell division, blood formation, and DNA synthesis, but folate is the form that the body can use directly, while folic acid must be converted in several steps to become active. Vitamin B9 is particularly important during periods of rapid cell division, such as during pregnancy, as it contributes to the normal development of the fetus's brain and spinal cord.
What is the difference between folic acid and methylfolate (5-MTHF)?
Folic acid is an inactive, synthetic form of vitamin B9 that must be converted in the body to its biologically active form, 5-methyl-tetrahydrofolate (5-MTHF), in order to be utilized. This conversion occurs with the help of an enzyme called MTHFR. However, up to 40% of the population has a genetic variation in the MTHFR gene (e.g., the C677T variant), which significantly impairs their ability to convert folic acid to active folate. For these individuals, regular folic acid supplements may be ineffective or even lead to the accumulation of inactive folic acid in the blood. Methylfolate, on the other hand, is already in its active form and can therefore be used directly by the body – regardless of genetic variations.
Why is folate important during pregnancy?
Folate plays a crucial role in the early development of the fetus, especially during the first weeks when the neural tube, which later becomes the brain and spinal cord, is formed. A deficiency of folate during this period can increase the risk of neural tube defects such as spina bifida. Therefore, both the National Institutes of Health (NIH) and the Swedish Food Agency recommend that women planning to become pregnant take supplements with 400–600 µg of folate daily. 5-MTHF L-Methylfolate is a superior choice as it ensures optimal availability even in women with reduced MTHFR function, making it the most bioactive and safe option during pregnancy.
What other benefits does folate have besides pregnancy?
In addition to supporting fetal development, folate contributes to normal blood formation, reduced fatigue and exhaustion, as well as normal psychological function. Folate is also important for regulating levels of homocysteine, an amino acid that at elevated levels is associated with an increased risk of cardiovascular disease. By participating in the methylation cycle, a process that affects DNA repair and detoxification, folate also plays a central role in cellular health and the body's ability to counteract inflammation and oxidative stress.
What does MTHFR mean and why is it relevant for folate?
MTHFR is a gene that codes for the enzyme methylenetetrahydrofolate reductase, which is necessary for converting folic acid into active 5-MTHF. Individuals with a genetic variation, particularly the homozygous C677T mutation, have reduced enzyme activity and thus a poorer ability to form active folate. This can lead to elevated homocysteine levels, fatigue, depression, fertility issues, or pregnancy complications. By taking 5-MTHF directly in its active form, this problem is completely bypassed – making the supplement particularly important for individuals with MTHFR variations.
What does 5-MTHF L-Methylfolate from Greatlife contain?
Each capsule contains 600 µg L-Methylfolate (Quatrefolic®), which corresponds to 300% of the daily reference intake. Quatrefolic® is a patented and highly stable form of 5-MTHF with high bioavailability, meaning that the body can quickly and effectively utilize the nutrients.
When and how should 5-MTHF L-Methylfolate be taken?
Take 1 capsule daily, preferably in the morning and with a meal. Since folate is water-soluble, it can be taken with or without food, but absorption is often slightly improved when taken with a meal. If you have difficulty swallowing, the capsule can be opened and the contents sprinkled on food or mixed in a drink.
Who can particularly benefit from 5-MTHF L-Methylfolate?
In addition to pregnant individuals and those with MTHFR gene variations, individuals experiencing fatigue, reduced concentration, or low mood may also benefit from active folate, as it is involved in the synthesis of neurotransmitters such as serotonin and dopamine. Additionally, people with high homocysteine levels, vegans, vegetarians, and those with impaired absorption in the gut (e.g., due to celiac disease or IBS) can greatly benefit from an active folate supplement.
Can you take 5-MTHF L-Methylfolate together with other supplements?
Yes, 5-MTHF works very well in combination with Vitamin B12 (Methylcobalamin) and Vitamin B6 (Pyridoxal-5-phosphate), which together participate in homocysteine metabolism and the methylation cycle. It is also common to combine it with iron (Blood Builder or Iron Response) during pregnancy to optimize blood values and reduce the risk of anemia.